Man dies after quitting smoking triggers fatal reaction to his medication
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A 29-year-old man from Worcester who suffered from paranoid schizophrenia has died after his decision to quit cigarettes turned his anti-psychotic medication fatally toxic.
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The tragedy has prompted a coroner to issue a prevention of future deaths report, warning no adequate guidance exists for medical practitioners on how to adjust clozapine dosages when patients cease smoking.
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Burton had been taking the drug nightly under the supervision of his community psychiatrist.He was prescribed a nightly dose of 525mg of clozapine, which was deemed the appropriate amount for someone who smoked heavily, as cigarettes are known to diminish the drug's efficacy.
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